Ask a longevity researcher to name one molecule that ties the whole field together and many will say the same thing: NAD+. It powers your metabolism, fuels your cellular repair crews, and — frustratingly — tends to run lower as the years go by.
What NAD+ does all day
- Energy. NAD+ is a key carrier in the reactions that convert food into usable cellular energy (ATP).
- Repair and signalling. NAD+ is the currency that sirtuins and PARP enzymes spend to maintain DNA and keep cellular housekeeping on schedule.
If you want the upstream story of how your body makes NAD+, start with What Is NMN?
The age-related decline
Multiple lines of research have reported that tissue NAD+ levels tend to fall with age across a range of organisms and human tissues. The review by Rajman, Chwalek & Sinclair (Cell Metabolism, 2018) gathers much of the in-vivo evidence for why NAD+ matters and what happens when it is restored in animal models.
Can you raise NAD+ again?
Because NAD+ itself is poorly absorbed by mouth, the practical approach is to supply a building block the body can convert. In a randomised, placebo-controlled study in Frontiers in Aging (2022), 300 mg of NMN daily increased the blood NAD+/NADH ratio by roughly 38% from baseline over 60 days, well above placebo (Frontiers in Aging, 2022).
Raising a lab value is not the same as feeling different, and it is important to be honest about that. But it does confirm the basic mechanism works in people.
What this means for you
Our NMN+ Daily Longevity formula is dosed in line with the human trials above and built on a clinically studied NMN ingredient. Every batch is third-party tested, and we publish the results on our Lab Reports page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This article is educational and is not medical advice.